Amongst Diablo runners it is common to edit adria's sound file. This adds no impact to the game other than potential comedic humor. Sound files are on average between 1-2 seconds in length, with the longer being cut off. Takes about ~5min to set up, can be done during Diablo setup.
Examples of Audio files:
"Abandon your foolish quest" (Diablo)
|Heh heh heh, thank you.||Diablo||Resident Evil Vendor||$381.51||(None)|
|Whacha buyin?||Diablo||Resident Evil Vendor||$165.00||(None)|
|Abandon your foolish quest||Diablo||Lazarus||$41.00||(None)|
|Default||Diablo||Adria speaks in her own voice||$25.00||(None)|
|Wee Wee Wee||Diablo||radio kappa/sodapoppin||$0.00||(None)|